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Pariacoto virus (PaV)

Pariacoto virus (PaV) is a T=3 virus with a bipartite genome containing a total of nucleotides.

Liang Tang determined the crystal structure of PaV when he was a postdoc in the laboratory of Jack Johnson. About 35% of the RNA genome is visible in the crystal structure, although it is not possible to assign specific nucleotides to specific positions in three-dimensional space, because of the icosahedral averaging used to determine the crystal structure.

In collaboration with Tang, Johnson and Anette Schneemann, we proposed a possible secondary structure for PaV RNA. In subsequent work my group published an all-atom model for the complete virus.

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As indicated above, it is not possible to assign specific nucleotides to specific positions in the crystal structure, so we used an artificial sequence (unrelated to the actual PaV genome) in the modeling work discussed above. We hope to determine the actual secondary structure of the PaV genome and then develop a final model for the structure of this virus.

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